Systems and methods for radiation treatment for determining a dose of radiation. Determining, for a tumor voxel, a value for maximum and minimum constraints, for treating the tumor voxel based on a distance function of a distance field of the tumor and distance fields of organs at risk (OARs). Each constraint on each tumor voxel is a function of a distance from the tumor voxel to a boundary of the tumor, and distances to boundaries of OARs. Determining, for an OAR voxel, a value of a maximum constraint based on the distance field of the tumor. Each constraint on each OAR voxel is a function of a distance from the OAR voxel to the boundary of the tumor. Determining a tumor constraint and a corresponding OAR constraint according to a threshold constraint set, to obtain the constraint set. Determine the dose of radiation, according to the constraint set.一種用於決定放射劑量之放射治療的系統和方法。對於腫瘤體素而言,基於該腫瘤的距離場和風險器官的距離場(OAR)的距離函數決定用於治療該腫瘤體素的最大和最小限制值。每個腫瘤體素上的每個限制是從該腫瘤體素到該腫瘤的邊界的距離以及與OAR的邊界的距離的函數。對於OAR腫瘤而言,基於該腫瘤的該距離場,決定最大限制的值。每個OAR體素上的每個限制是從該OAR體素到該腫瘤的該邊界的距離的函數。根據閾值限制集決定腫瘤限制和相應的OAR限制,以獲得該限制集。根據該限制集決定該放射劑量。100‧‧‧方法110、115、120、125‧‧‧步驟108‧‧‧桌子109‧‧‧身體140‧‧‧處理器150‧‧‧診斷系統152‧‧‧感測器180‧‧‧放射實施系統182‧‧‧放射源
