A system and method for producing an image of a subject with a tomographic imaging system are provided. A tomographic imaging system is operated to rotate a radiation detector, radiation source, or both through a plurality of angular positions around a subject while acquiring data. As the radiation detector or source is rotated, the radiation detector or source is shifted at each angular position by a different shift value. An image of the subject is reconstructed from the acquired data using a reconstruction technique that incorporates the shifts applied to the detector, source, or both into a system matrix.
