Pascal Furet,Robert Martin Grotzfeld,Wolfgang Jahnke,Darryl Jones,Paul William Manley,Andreas Marzinzik,Xavier Francois Andre Pelle,Bahaa Salem,Joseph Schoepfer
申请号：
US15075620
公开号：
US09896444B2
申请日:
2016.03.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to compounds of formula (I):in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention capable of inhibiting the tyrosine kinase enzymatic activity of the Abelson protein (ABL1), the Abelson-related protein (ABL2) and related chimeric proteins, in particular BCR-ABL1. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
