This disclosure provides systems and methods for cosmetic enhancement of lips. The systems and methods can include a treatment device including an energy source, a coupling material, a control module, and a housing. The systems and methods can generate and deliver an energy to the region of interest non-invasively to drive a cosmetic process about the lip or a physiological effect in the lip. The systems and methods can control the generation of the energy based on at least one of the physiological effect in the lip, a duration of generating the energy, a user input, and a temperature associated with the region of interest.
