SHANGHAI INSTITUTE OF MATERIA MEDICA; CHINESE ACADEMY OF SCIENCES
发明人:
Fajun Nan,Min Li,Zhaobing Gao,Yangming Zhang,Haining Hu,Haiyan Xu,Huanan Liu,Xiaoping Pi
申请号：
US15306971
公开号：
US10077245B2
申请日:
2015.04.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.
