A prefilled syringe consists of a syringe cylinder (2) which is open at one axial side and is closed by a plunger and which has a Luer lock connection (4) on the other axial side, said lock being molded on an end wall (3) which closes the syringe cylinder (2). The syringe comprises a flowable medium (8) which is filled into the syringe cylinder (2), a soft-elastic stopper (9) which closes at least the Luer (5), and a tamper-evident closure (15) which surrounds the outside of the stopper (9) and which has a predetermined breaking point. The syringe cylinder (2), the end wall (3), and the Luer lock connection (4) are formed as a single piece in the form of a transparent injection-molded plastic part. The tamper-evident closure (15) consists of the same or a similar plastic as the syringe cylinder (2) and is welded to the end wall (3) of the syringe cylinder (2). The welding connection forms the predetermined breaking point, and the stopper (9) is integrated into the tamper-evident closure (15).
