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SAP variants and uses thereof
专利权人:
プロメディオール, インコーポレイテッド;インコーポレイテッド;プロメディオール,
发明人:
ダブリュー・スコット・ウィレット
申请号:
JP2015090887
公开号:
JP6124943B2
申请日:
2015.04.27
申请国别(地区):
JP
年份:
2017
代理人:
摘要:
Polypeptides are susceptible to denaturation or enzymatic degradation in the blood, liver or kidney. Due to the low stability of some polypeptides, it has been required to administer polypeptide drugs in a sustained frequency to a subject in order to maintain an effective plasma concentration of the active substance. Furthermore, pharmaceutical compositions of therapeutic peptides preferably have a shelf- life of several years in order to be suitable for common use. However, peptide compositions are inherently unstable due to sensitivity towards chemical and physical degradation. In part, the invention provides SAP variant proteins, compositions, pharmaceutical preparations and formulations having a prolonged in vivo half-life, prolonged shelf-life, or rather increased in vitro stability, or increased manufacturing efficiency compared to human SAP. Advantages of increased plasma half-life include, but are not limited to, reducing the amount and/or frequency of dosing.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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