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comprising a solubilizing agent to help extending stability duration in an emulsion
专利权人:
TIANJIN TASLY GROUP CO.; LTD
发明人:
CHEN, JIAN-MING,陈建明,陳建明,GAO, BAO-AN,高保安,高保安,SUN, JING,孙靖,孫靖,DENG, LI,邓莉,鄧莉,YANG, QIU-XIA,杨秋霞,楊秋霞,LIU, WEI,刘薇,劉薇,GU, PENG,顾芃,顧芃,ZHANG, YING-YING,张莹莹,張瑩瑩,ZHANG, JIA-LIANG,张佳良,張佳良
申请号:
TW099138730
公开号:
TW201219056A
申请日:
2010.11.10
申请国别(地区):
TW
年份:
2012
代理人:
摘要:
The present invention provides a taxane pharmaceutical solution containing solubilizing agent and a method for preparing same, and a combination usage of the pharmaceutical solution and emulsion. In clinic use, the pharmaceutical solution is dispersed in the emulsion and shaken uniformly and then applied through intravenous injection. Due to the inclusion of the solubilizing agent, the stability duration of the pharmaceutical solution dispersed in the emulsion is surprisingly extended and the surface oil problem of the dispersion liquid is also overcome, thereby helping improving clinically pharmaceutical safety and effectiveness. The present invention also provides a method for preparing a taxane pharmaceutical solution, a composition containing taxane pharmaceutical solution and emulsion, and a combined package composed of taxane pharmaceutical solution and emulsion.本發明提供了一種含有助溶劑的紫杉烷類藥物溶液及其製備方法,以及該藥物溶液與乳劑的組合應用。臨床用藥前,將藥物溶液分散在乳劑中,搖勻,即可靜脈滴注。由於助溶劑的加入,意想不到地延長了藥物溶液分散在乳劑中的穩定時間,同時克服了分散液表面浮油的問題,進一步提高了臨床用藥的安全性與有效性。本發明還進一步提供了紫杉烷類藥物溶液的製備方法、含有紫杉烷類藥物溶液和乳劑的組合物以及由紫杉烷類藥物溶液和乳劑組成的組合包裝。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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