New pyrrolotriazinone derivatives having the chemical structure of formula (I) are disclosed as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).本發明描述一種新穎的具有化學式(I)之化學結構之吡咯三嗪酮衍生物;以及其製備製程、包含其之醫藥組成物及其使用於作為磷脂醯肌醇-3-激酶(Phosphoinositide 3-Kinases,PI3Ks)抑制劑之治療。