귈레몽 제롬 에밀 조지,파스퀴에르 엘리자베스 테레세 장,란코이스 데이비드 프란시스 알랜,안드리스 코엔라드 요제프 로데비이크 마르셀,코울 아닐,백스 레오 야코부스 요제프,메르포엘 리벤
申请号：
KR1020087005071
公开号：
KR1014139970000B1
申请日:
2006.07.31
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
compound for the manufacture of a medicament for the treatment of bacterial infections, mycobacterial infections, except for, the formula (I), a pharmaceutically acceptable acid or base addition salts chemical, quaternary amine, stereochemical isomer, a tautomer or N- oxide forms of use are disclosed:wherein,R 1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxy-alkyl, alkylthio-alkyl, Ar- alkyl or di (Ar) alkylp is an integer from 1 to 3s is an integer from 0 to 4R 2 is hydrogen Halo Alkyl Hydroxy Mercapto Optionally substituted alkyloxy Alkyloxy-alkyloxy Alkylthio Mono or di (alkyl) amino (wherein alkyl is optionally may be substituted) Ar Het or expression of radicals andR 3 is alkyl, Ar, Ar- alkyl, Het or Het- alkylq is an integer from 0 to 4R 4 and R 5 are each independently selected from hydrogen, alkyl or benzylR 4 and R 5 may be bonded together, including the N to which they are bondedR 6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy , alkylthio, alkyloxy-alkyl, alkylthio-alkyl, Ar- alkyl or di (Ar) alkyltwo adjacent R 6 radical together, may form a phenyl ring which they are attached a naphthylr is an integer from 1 to 5 andR 7 is hydrogen, alkyl, Ar or Het isR 8 is hydrogen, alkyl, hydroxy hydroxyl, aminocarbonyl, mono or di (alkyl) aminocarbonyl, Ar, Het, 1 or 2 alkyl substituted by Het, or alkyl substituted by one or two Ar, Het-C (= O) - or Ar-C (= O) - orHowever, R 3 is located in section 3 of the quinolineR 7 is located in the part 4 of the quinolineR 2 is located in the part 2 of the quinoline, hydrogen, hydroxy, mercapto, alkyl aryloxy, alkyloxy-alkyloxy, alkylthio, mono or di (alkyl) amino or a group represented by the formula in the case of radicals.s is 1 to 4마이코박테리아 감염을 제외한 박테리아 감염 치료용 약제를 제조하기 위한, 화학식 (I)의 화합물, 그의 약제학적으로 허용되는 산 또는 염기 부가염, 사차 아민, 입체화학적 이성체, 토토머 또는 N-옥사이드 형태의 용도가 개시된다:상기 식에서,R1은 수소, 할로, 할로알킬, 시아노, 하이드록시, Ar, Het, 알킬, 알킬옥시, 알킬티오, 알킬옥시알킬, 알킬티오알킬
