Porcine circovirus (PCV2) vaccine compositions comprising a peptide antigen derived from a PCV2 capsid protein are described. In various embodiments, the peptide antigen contains amino acids of the capsid protein from about amino acid 47 to about amino acid 202. In some embodiments, the peptide antigenis optionally linked to an artificial T helper eptiope and/or mixed with T helper epitopes derived from the ORF1 and ORF2 protein of PCV2. Methods of using PCV2 vaccine compositions are also described. In various embodiments, a vaccine composition is used in animals for the prevention of PCV2 infection. In other embodiment, a PCV2 vaccine composision is used as an antigen for diagnosing PCV2 infection.本發明提供一種包含源自PCV2鞘蛋白胜肽抗原的第二型豬環狀病毒疫苗。在多個實施例中,此胜肽抗原包括鞘蛋白約第47個位置至約第202個位置的胺基酸。在數個實施例中,此胜肽抗原選擇性與一人工合成之輔助型T細胞抗原決定位連結及/或與源自PCV2之ORF1與ORF2蛋白之輔助型T抗原決定位混合。本發明更提供使用PCV2疫苗組成物的方法。在多個實施例中,疫苗組成物被使用於動物中以防止PCV2的感染。在另一實施例中,PCV2疫苗組成物被作用一抗原用以診斷PCV2的感染。
