A synthetic nutritional composition comprising at least one N-acetyl-lactosamine, at least one sialylated oligosaccharide and at least one fucosylated oligosaccharide, for use in the prevention and / or treatment of skin diseases, preferably atopic dermatitis, in that N-acetyl-lactosamine is selected from the group consisting of lacto-N-tetraose and lacto-N-neotetraose, and wherein the sialylated oligosaccharide is selected from the group consisting of 3'-sialillactose and 6'- sialillactose, and preferably said composition comprises both 3'-sialillactose and 6'-sialillactose, the ratio being between 3'-sialillactose and 6'-silalillactose preferably in the range between 5: 1 and 1: 2, and in which the oligosaccharide Fucosylated is selected from the group consisting of 2'-fucosillactose, 3-fucosillactose, difucosillactose, lacto-N-fucopentaose I, lacto-N-fucopentaose II, lacto-N-fucopentaose III and lacto-N-fucopentaose V, lacto- N-difucohexaosa I, fu cosillacto-N-hexaosa, Difucosillacto-N-hexaosa I and Difucosillacto-N-neohexaosa II, and preferably the fucosylated oligosaccharide is 2'-fucosillactose (2-FL).Una composición nutricional sintética que comprende al menos una N-acetil-lactosamina, al menos un oligosacárido sialilado y al menos un oligosacárido fucosilado, para su uso en la prevención y/o el tratamiento de enfermedades de la piel, preferiblemente dermatitis atópica, en la que la N-acetil-lactosamina se selecciona entre el grupo que consiste en lacto-N-tetraosa y lacto-N-neotetraosa, y en la que el oligosacárido sialilado se selecciona entre el grupo que consiste en 3'-sialillactosa y 6'-sialillactosa, y preferiblemente dicha composición comprende tanto 3'-sialillactosa como 6'-sialillactosa, encontrándose la razón entre 3'-sialillactosa y 6'-silalillactosa preferiblemente en el intervalo entre 5:1 y 1:2, y en la que el oligosacárido fucosilado se selecciona entre el grupo que consiste en 2'-fucosillactosa, 3-fucosillactosa, difucosillactosa, lacto-N-fucop
