THE REGENTS OF THE UNIVERSITY OF COLORADO; A BODY CORPORATE
发明人:
Robert S. HODGES,Ziqing JIANG,Lajos GERA,Colin T. MANT
申请号：
US16606454
公开号：
US20200129634A1
申请日:
2018.04.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Antimicrobial agents, including antimicrobial peptides (AMPs), and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type antimicrobial peptide variants that demonstrate activity and improved therapeutic indices against microbial pathogens. The peptide compositions demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms Acinetobacter baumannii and Pseudomonas aeruginosa, but also significantly decrease hemolytic activity against human red blood cells. Specificity determinants within the AMPs change selectivity from broad spectrum antimicrobial activity to Gram-negative selectivity.
