The Board of Trustees of the University of Illinois
发明人:
Sheena N. Smith,Daniel T. Harris,David M. Kranz
申请号：
US15037476
公开号：
US10023625B2
申请日:
2014.11.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of mutational libraries of TCRs in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast (i.e. directed evolution). In embodiments, the engineered TCRs can be used in soluble form for targeted delivery in vivo, or as genes introduced into T cells in an adoptive T cell setting.
