您的位置：
首页
>
农业专利
>
详情页
mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY
- 专利权人:
- SIGNAL PHARMACEUTICALS; LLC
- 发明人:
- ELSNER, JAN,HARRIS, ROY, L,LEE, BRANDEN,MORTENSEN, DEBORAH,PACKARD, GARRICK,PAPA, PATRICK,PERRIN-NINKOVIC, SOPHIE,RIGGS, JENNIFER,SANKAR, SABITA,SAPIENZA, JOHN,SHEVLIN, GRAZIELLA,TEHRANI, LIDA,XU, WEI
- 申请号：
- NZ59227809
- 公开号：
- NZ592278A
- 申请日:
- 2009.10.27
- 申请国别(地区):
- NZ
- 年份:
- 2013
- 代理人:
- 摘要：
- Disclosed is a compound having formula (II) e.g. 7-(6-(1H-1 ,2,4-triazol-3-yl)pyridin-3-yl)-1-( cis-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one or a pharmaceutically acceptable salt, clathrate, solvate, stereoisomer, tautomer, or prodrug thereof, wherein R1, R2 and R3 are defined in the specification for treating multiple myeloma, mantle cell lymphoma, diffused large B-cell lymphoma, acute myeloid lymphoma, follicular lymphoma, chronic lymphocytic leukemia breast, lung, endometrial, ovarian, gastric, cervical, or prostate cancer glioblastoma renal carcinoma hepatocellular carcinoma colon carcinoma neuroendocrine tumors head and neck tumors sarcomas tumor syndromes resulting directly or indirectly from genetic defects in PTEN, TSC1, TSC2, NFl, AMPK, LKB1, VHL or PKD1 Cowdens disease, Cowden syndrome, Cowden-like syndrome, Bannayan-Zonana syndrome, Bannayan-Riley-Ruvalcaba syndrome, Lhermitte-Duclos disease, endometrial carcinoma, tuberous sclerosis complex, lymphangioleiomyomatosis, neurofibromatosis 1, Peutz-Jeghers syndrome, renal cell carcinoma, von Hippel-Lindau disease, Proteus syndrome, or polycystic kidney disease rheumatoid arthritis rheumatoid spondylitis osteoarthritis gout asthma, bronchitis allergic rhinitis chronic obstructive pulmonary disease cystic fibrosis inflammatory bowel disease irritable bowel syndrome mucous colitis ulcerative colitis Crohn s disease Huntingtons disease gastritis esophagitis hepatitis pancreatitis nephritis multiple sclerosis lupus erythematosus atherosclerosis restenosis following angioplasty left ventricular hypertrophy myocardial infarction stroke ischemic damages of heart, lung, gut, kidney, liver, pancreas, spleen and brain acute or chronic organ transplant rejection preservation of the organ for transplantation organ failure or loss of limb graft versus host disease endotoxin shock multiple organ failure psoriasis bum from exposure to fire, chemicals or radiation eczema dermatitis skin graft ischemia
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
