PROBLEM TO BE SOLVED: To provide an endoscope system capable of accurately measuring a degree of oxygen saturation of an observation object, and achieving excellent visibility of a fine structure such as a surface blood vessel, and to provide a light source device, an operation method of the endoscope system, and an operation method of the light source device.SOLUTION: An endoscope system 10 includes a light source part 20, a band restriction part 21, a light source control part 22, an imaging sensor 48, an imaging control part 52, and a degree-of-oxygen saturation image generation part 64. The light source part 20 includes a V-LED 20a for emitting violet light V, a B-LED 20b for emitting blue light B, a G-LED 20c for emitting green light G, and an R-LED 20d for emitting red light R. The band restriction part 21 generates measurement light BL having a specific wavelength band for measuring a degree of oxygen saturation from the blue light B. The light source control part 22 switches the control of the light source part between a first light emission mode for applying the violet light V, the measurement light BL, the green light G, and the red light R to an observation object, and a second light emission mode for applying the measurement light BL to the observation object.COPYRIGHT: (C)2016,JPO&INPIT【課題】観察対象の酸素飽和度を正確に測定可能であり、かつ、表層血管等の微細構造の視認性が良い内視鏡システム、光源装置、内視鏡システムの作動方法、及び光源装置の作動方法を提供する。【解決手段】内視鏡システム10は、光源部20と、帯域制限部21と、光源制御部22と、撮像センサ48と、撮像制御部52と、酸素飽和度画像生成部64と、を備える。光源部20は、紫色光Vを発するV-LED20aと、青色光Bを発するB-LED20bと、緑色光Gを発するG-LED20cと、赤色光Rを発するR-LED20dとを有する。帯域制限部21は、青色光Bから、酸素飽和度を測定するための特定波長帯域を有する測定光BLを生成する。光源制御部22は、紫色光Vと測定光BLと緑色光Gと赤色光Rとを観察対象に照射する第1発光モードと、測定光BLを観察対象に照射する第2発光モードとで光源部の制御を切り替える。【選択図】図10