The present invention, as well as macrocyclic compounds having therapeutic activity will be described how to modulate bone process, and how, as well as the treatment of disorders such as how bone-related diseases, disorders, and to treat the symptoms. [Selection] Figure Figure 1本発明は、治療活性を有する大環状化合物、ならびに、骨プロセスを調節する方法、ならびに骨関連疾患、障害、およびその症状を治療する方法などの障害を治療する方法について説明する。【選択図】図1