THIS INVENTION RELATES TO A RICH ANTIOXIDANT NUTRACEUTICALS PREPARED FROM NIGELLA SATIVA SEEDS FOR THE TREATMENT AND PREVENTION OF HYPERCHOLESTEROLEMIA. THESE NUTRACEUTICALS WHEN TAKEN ENTERALLY HAS SHOWN SUCCESSFULLY TO HAVE HYPOCHOLESTEROLIMIC. ANTIATHEROGENIC AND ANTIOXIDANT ACTIVITIES USING IN VITRO AND IN VIVO STUDY. TILE INVENTION PROVIDES A CLEAR EXPLANATION ON THE MOLECULAR MECHANISM BY WHICH NUTRACEUTICALS PREPARED FROM THE NIGELLA SATIVA SEEDS EXERTED ITS HYPOCHOLESTEROLEMIC EFFECT.