A multivalent immunogenic composition comprising 15 distinct polysaccharide-protein conjugates is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (serotypes 1, 2, 3, 4, 5, 6A, 6B, 7F, 9N, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The multivalent immunogenic composition, formulated as a vaccine comprising an aluminum-based adjuvant, increases coverage for pneumococcal disease in infants and young.描述一種多價免疫性組成物,其包含15個相異的多醣-蛋白質共軛物。各共軛物含有與一種載體蛋白共軛結合、製備自不同血清型的肺炎鏈球菌之莢膜多醣(血清型1、2、3、4、5、6A、6B、7F、9N、9V、14、18C、19A、19F和23F)。該多價免疫性組成物,調配成包含鋁基的佐劑之疫苗,增加了嬰兒和青年的肺炎球菌疾病之涵蓋範圍。
