Ashvinikumar V. Gavai,Yufen Zhao,Daniel OMalley,Claude A. Quesnelle,Brian E. Fink,Derek J. Norris,Wen-Ching Han,George V. DeLucca
申请号：
US14429935
公开号：
US09242941B2
申请日:
2013.09.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein: R1 is CH2CH2CF3 R2 is CH2(cyclopropyl), CH(CH3)(cyclopropyl), or CH2CH2CH3 R3 is H, CH3, or Rx R4 is H or Ry and Rx, Ry, Ra, Rb, Rc, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer. The compounds of Formula (I) also include prodrugs of the Notch inhibitor compounds.
