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DEVICE FOR LOCAL AND / OR REGIONAL DELIVERY USING LIQUID COMPOSITIONS OF THERAPEUTICALLY ACTIVE SUBSTANCES
专利权人:
КОРДИС КОРПОРЕЙШН
发明人:
ЧЖАО Джонатон З.
申请号:
RU2014102013
公开号:
RU2014102013A
申请日:
2009.03.30
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A drug delivery device, comprising: an expandable member having an outer surface and configured such that the outer surface is in contact with surrounding tissue when the expandable member expands; a liquid composition of a therapeutically active substance attached to the outer surface of the expandable element and made to release into the surrounding tissue when the outer surface of the expandable element is in contact with the surrounding tissue, while the liquid composition contains a taxane in a pharmacologically effective dosage of at least one pharmacologically acceptable solubility enhancer and water in a concentration range from about one percent by weight to about seventy percent by weight, and liquids composition comprises a final solution of taxane in the concentration range from about 0.05 mg / ml to about 15 mg / ml.2. The drug delivery device of claim 1, wherein the expandable member comprises a stent. 3. A drug delivery device according to claim 1, wherein the expandable member comprises a balloon. A drug delivery device according to claim 1, wherein the liquid composition further comprises at least one pharmacologically acceptable stabilizer. The drug delivery device of claim 4, wherein the taxane contains paclitaxel. A drug delivery device according to claim 4, wherein at least one pharmacologically acceptable stabilizer and solubility enhancer comprise polyethylene glycol. The drug delivery device of claim 4, wherein the at least one pharmacologically acceptable stabilizer and solubility enhancer comprise vitam1. Устройство для доставки лекарства, содержащее:расширяемый элемент, имеющий внешнюю поверхность и выполненный так, что внешняя поверхность контактирует с окружающей тканью, когда расширяемый элемент расширяется; ижидкий состав терапевтически активного вещества, присоединенный к внешней поверхности расширяемого элемента и выполненный для высвобождения в окружающую ткань, когда внешняя поверхность расширяемого элемента контактирует с окруж
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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