Yong Y. LIN;Shuren MA;Toyonobu USUKI;Gerard M. TURINO
发明人:
Yong Y. Lin,Shuren Ma,Gerard M. Turino,Toyonobu Usuki
申请号：
US14888075
公开号：
US20160103138A1
申请日:
2014.04.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides, inter alia, methods for measuring the amount of a marker of elastic fiber injury in a sample. The methods include contacting a sample with a compound of formula (1) and carrying out mass spectrometry on the sample containing the compound of formula (1). Also provided are methods of diagnosing whether a subject has a disease characterized by elastic fiber injury, a method for improving the accuracy and precision of mass spectroscopy analysis of a marker of elastic fiber injury, and kits for determining, by mass spectrometry, the amount of a marker of elastic fiber injury in a sample from a subject. Further provided are methods for preventing the progression of the effects associated with alpha-1 antitrypsin deficiency (AATD) in a subject with normal lung function.
