Richard N. Kolesnick,Branka Stancevic,Michel Sadelain,Zvi Fuks,Nira Varda-Bloom,Dror Harats
申请号：
US13513890
公开号：
US20120252883A1
申请日:
2010.12.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed herein are methods and compositions for treating cancer by increasing radiation-induced damage to cancer without increasing radiation-induced side effects by increasing secretory ASMase levels specifically in tumor endothelium, and inducing apoptosis of tumor endothelial cells by treating the tumor with radiation. ASMase levels are increased in tumor endothelium by administration of a recombinant DNA construct comprising a region coding for a functional ASMase linked to particular transcriptional regulatory sequences that confer tissue-specific expression of ASMase.
