This invention captures and teaches the high-level method of combining doses of medications in unconventionally substandard amounts for the cooperative treatment of medical pathologies with the end product of a pharmaceutical composition. By combining multiple medications, each treating the same disease process and each in a calculated substandard dosage, it is rational to allow for greater comprehensive efficacy while simultaneously bypassing conventional side-effects, clinically significant medication interactions, and other potentially unforeseen deleterious effects, all because the dosage composition is small enough individually and collaborative chemical diversity manifests favorable kinetic dynamics, thereby mitigating unwanted drug effects while enhancing the targeted indication.