SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION;서울대학교산학협력단
发明人:
PARK, Joo-Cheol,박주철,LEE, Dong-Seol,이동설,PARK, Yeoung-Hyun,박용현
申请号：
KRKR2019/000439
公开号：
WO2019/143070A1
申请日:
2019.01.11
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present application discloses a periodontal ligament regenerating composition comprising CPNE7 and a periodontal ligament regenerating method. A composition and a method according to the present application can regenerate the periodontal ligament by expediting the formation of cementum and periodontal ligament through the promotion of differentiation and calcification of periodontal ligament fibroblasts into cementoblasts. The composition and the method according to the present application can promote the attachment of the cementum and alveolar bone of the newly formed periodontal ligament and repress tooth ankylosis, which induces the atrophy of tooth tissues, thus finding useful applications in the fundamental treatment of disorders that requires the restoration of damaged connective tissues, such as periodontal disorders and luxation injuries of teeth.La présente invention concerne une composition de régénération de ligament parodontal comprenant CPNE7 et un procédé de régénération de ligament parodontal. Une composition et un procédé selon la présente invention peuvent régénérer le ligament parodontal en accélérant la formation de cément et de ligament parodontal en favorisant la différenciation et la calcification de fibroblastes de ligament parodontal en cémentoblastes. La composition et le procédé selon la présente invention peuvent favoriser la fixation du cément et de l'os alvéolaire du ligament parodontal nouvellement formé et réprimer l'ankylose dentaire, ce qui induit l'atrophie de tissus dentaires, trouvant ainsi des applications utiles dans le traitement fondamental de troubles qui nécessitent la restauration de tissus conjonctifs endommagés, tels que des troubles parodontaux et des lésions de luxation des dents.본원은 CPNE7을 포함하는 치주인대 재생용 조성물 및 방법을 개시한다. 본원에 따른 조성물 및 방법은 치주인대 섬유모세포의 백악모세포로의 분화와 석회화 촉진을 통한 백악질 형성 및 치주인대 형성을 촉진하여, 치주인대를 재생할 수 있다. 본원에 따른 조성물 및 방법은 새롭게 형성된 치주인대의 백악질 및 치조골의 부착을 촉진하고, 또한 치아조직의 퇴화를 유도하는 치아-골유착의 형성을 억제할 수 있어, 치주질환 및 탈구성 외상 치
