Damaj Bassam,Martin Richard,Mueller Michael,Daniel W. Frank
申请号：
NZ71574212
公开号：
NZ715742A
申请日:
2012.07.06
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
A reconstitution device, particularly a reconstitution device for combining two separated components of a pharmaceutical composition. The reconstitution device comprising a first (12, see figure 10) and second (14) housings, a conduit, a first (50), second (52) and third (54) plunger, a plunger rod, a moveable member and a shearing channel (32). The first and second housings are immovably engageable together. The conduit comprises an internal passageway, formed in the first housing, the internal passageway having a dispensing end and an inlet end. The first plunger is mounted within the passageway, proximate the dispensing end. The second plunger is mounted within the passageway, proximate the inlet end. The third plunger is mounted within the passageway intermediate the first and second plungers, the three plungers defining a first compartment (74) and a second compartment (76). The plunger rod extends at least partially within the internal passageway and may comprise a shaft (60) and an enlarged head (62). The moveable member is located within the second housing and engages the first plunger. The shearing channel is formed in the side wall of the conduit and permits the mixing of the contents located in the first and second compartments. Preferably, when the plunger rod is depressed the plungers translate along the channel until a first component (72) may travel via the shearing channel and mix with a second component (70), within the first compartment. The plunger is then allowed to return upwards, the moveable member acting on the first plunger to transfer the composition comprising both components into the second compartment. The first and second housings may be decoupled allowing the composition to be applied from the dispensing end of the internal passageway. Also disclosed is a method of filling the reconstitution device comprising placing, within the internal passageway, the first plunger, the first component, the third plunger, the second component, the se
