Andrew Lennard Lewis,Yiqing Tang,Maria Victoria Gonzalez Fajardo
申请号:
US13160935
公开号:
US08586098B2
申请日:
2011.06.15
申请国别(地区):
US
年份:
2013
代理人:
摘要:
A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.