The present invention relates to method (MC4R) activity for enhancing normal melanocortin-4 receptor, have the MC4R for being mutated which influence protein folding and/or processing to enhance active MC4R. The present invention provides a kind of individuals for the treatment of to have condition, wherein increased activity MC4R battery surfaces will be beneficial, such as obesity, by the MC4R for giving a effective amount of drug molecule companion. The present invention provides the activity of which enhancing MC4R of MC4R pharmacological chaperones. The present invention also provides a kind of screenings, to identify the endoplasmic reticulum (ER) of the MC4R of the pharmacological chaperones of which enhancing folding, in order to improve the activity of MC4R in cell surface.
