JOHNSON, BARBARA JANE,SUHRBIER, ANDREAS,NAYLOR, DEAN JASON,DOBBIN, CAROLINE AMANDA,HOWARD, CHRISTOPHER BRUCE
申请号：
AT05700073
公开号：
AT548047T
申请日:
2005.01.14
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.
