Low density lipoprotein-like (LDL-like) cationic nanoparticles for nucleic acid transfer, method for producing the same, and method for transferring nucleic acid using the same

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专利权人:

韓国科学技術院;サムヤン コーポレイション

发明人:

パク，テグァン,キム，ヒュンリュン,キム，インキュン,パク,テグァン,キム,ヒュンリュン,キム,インキュン

申请号：

JP2010529879

公开号：

JP5336500B2

申请日:

2008.10.17

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

Disclosed are a LDL-like cationic nanoparticle for delivering a nucleic acid gene with improved transfection efficiency and stability, which is surface modified and re-constructed by mimicking lipid components of a natural LDL, a method for preparation of the same, and a method for delivering nucleic acid genes using the same. The cationic nanoparticle of the present invention could effectively be applied in treatment of cancer that overexpress LDL receptors.

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中国工程科技知识中心

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