Jon O. Rayner,Jonathan F. Smith,Bolyn Hubby,Elizabeth A. Reap
申请号：
US14792247
公开号：
US09441247B2
申请日:
2015.07.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.
