COMPOSITIONS COMPRENANT DES CONSTRUCTIONS GENETIQUES D'IL-12 AMELIORES ET DES VACCINS AMELIORES, PRODUITS IMMUNOTHERAPEUTIQUES ET PROCEDES D'UTILISATION ASSOCIES

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

WEINER, DAVID B.,MORROW, MATTHEW P.,YAN, JIAN

申请号：

CA2858893

公开号：

CA2858893A1

申请日:

2012.12.11

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL-12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.

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