WATTIEZ, Ruddy,MASTROLEO, Felice,SUTERS, Robertus Christiaan Josephus
申请号：
EPEP2018/065878
公开号：
WO2018/229223A1
申请日:
2018.06.14
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
The present invention relates to a low-density lipoprotein (LDL)-cholesterol-lowering preparation, in particular to a bacterial cell extract for use as a medicament for lowering of the blood plasma LDL- cholesterol level, wherein the extract is obtained by extraction for between 10 minutes and 48 hours at between 8°C and 37°C, while mixing the cells with the mixture, and wherein the ldl-cholesterol-lowering cell extract and food supplementldl-cholesterol-lowering cell extract and food supplement Rhodospirillum rubrum cells are extracted with the mixture in a volume ratio of between 10:1 and 1:10 of petroleum ether with a boiling point of between 60°C and 80°Cand methanol comprising sodium chloride. More specifically, the present invention relates to a petroleum ether extract of Rhodospirillum rubrum obtainable by extraction of Rhodospirillum rubrum cells with a mixture of petroleum ether with a boiling point of between 60°C and 80°C and methanol comprising sodium chloride. The invention also relates to the petroleum ether extract of Rhodospirillum rubrum of the invention, for use in a method for the lowering of LDL-cholesterol in blood plasma of a subject.The invention further relates to a pharmaceutical preparation, a food supplement containing said preparation, a foodstuff containing said food supplement, and to a method for their preparation.La présente invention concerne une préparation abaissant la cholestérolémie à lipoprotéines de basse densité (LDL), en particulier un extrait de cellule bactérienne destiné à être utilisé à titre de médicament pour abaisser la cholestérolémie LDL plasmatique, où lextrait est obtenu par extraction pendant 10 minutes à 48 heures à une température comprise entre 8 et 37°C, tout en incorporant les cellules au mélange, et où les cellules de Rhodospirillum rubrum de lextrait cellulaire abaissant la cholestérolémie LDL et du complément alimentaire le contenant sont extraites à laide dudit mélange constitué, dans un rapport en volume
