A method of treating or preventing a condition caused by a biofilm in a subject is carried out by: providing a subject having, or susceptible to, a condition mediated by a biofilm produced by a microorganism, where the biofilm comprises a matrix and the microorganism on a surface and administering to the subject an active agent under conditions effective for the condition caused by a biofilm in the subject to be treated or prevented, where the active agent is a compound of general Formula (I): or a pharmaceutically acceptable salt thereof.