Stabilized lipid formulation of apoptosis promoter

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专利权人:

AbbVie Inc.

发明人:

Catron, Nathaniel,Fickes, Michael,Fischer, Cristina,Haight, Anthony R.,Heemstra, Katherine,Sanzgiri, Yeshwant,Schmitt, Eric,Tong, Ping,Zhang, Geoff,Zhou, Deliang

申请号：

AU2010242926

公开号：

AU2010242926B2

申请日:

2010.04.30

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

An orally deliverable pharmaceutical composition comprises a Bcl-2 family protein inhibitory compound, e.g., ABT-263, a heavier-chalcogen antioxidant and a substantially non-aqueous lipid carrier, wherein said compound and said antioxidant are in solution in the carrier. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

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