DUAN, ZHIYONG,LIU, YONGCAI,LAO, YE,CHEN, DONG,MA, JUN
申请号：
EP11856630
公开号：
EP2557938A4
申请日:
2011.01.17
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
A protected &alpha；-amylase is described. Pelletization and encapsulation technology, in which slow-release materials and pH-sensitive materials are used to protect the &alpha；-amylase from inactivation at low pH. The protected &alpha；-amylase was found to be highly stable after as long as 3-hour treatment in acid (pH 3.0). When treated in pH 3.0 for 1 hour and followed by treatment with lipase and pancreatin in pH 7.0 for 2 hour to simulate in vivo environment, it was found that &alpha；-amylase was fully released and measurable. In addition, the protected &alpha；-amylase showed superior efficacy to the unprotected &alpha；-amylase. The protected &alpha；-amylase also demonstrated enhanced thermostability.
