Isoliquiritigenin Suppresses human T lymphocyte activation via targeting on cysteine 46 of IKBA Kinase

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专利权人:

Macau University of Science and Technology

发明人:

LIU, Liang,LI, Ting,YAN, Feng Gen

申请号：

AU2015100662

公开号：

AU2015100662A4

申请日:

2015.05.20

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

#$%^&*AU2015100662A420150611.pdf#####ABSTRACT The present invention provides a compound, Isoliquiritigenin, which could inhibit immunesuppressive effect resulted from direct interaction with IKK-P C46A in vivo and in vitro. Isoliquiritigenin effectively inhibits the immune-suppressive effects through regulation of T lymphocytes by inhibiting T cells proliferation and division, suppressing expression of CD69 and CD 25 as well as up-regulating CD71 in a dose-dependent manner. The present invention also provides a method of screening therapeutic agents for treating autoimmune diseases. 17

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中国工程科技知识中心

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http://www.ckcest.cn/home/