The present invention addresses the problem of discovering an effective cancer therapy method and providing a medicine. Provided is a medicine comprising a combination of a compound represented by general formula (I), a salt, solvate or N-oxide of the compound or a prodrug of the compound or the salt, solvate or N-oxide and an immune checkpoint inhibitor (e.g., an anti-PD-1 antibody). The combination according to the present invention exhibits a high anti-tumor effect and is therefore useful for the treatment of cancer.
