INTRANASAL DELIVERY OF LIPOSOMAL SCHIFF BASE ALOIN IN THE ALVEOLAR MACROPHAGES AGAINST IRON DEPOSITION

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专利权人:

HIPOLITO; MARILENE C.

发明人:

MARILENE C. HIPOLITO,BLANCA MARIE B. HERMANO

申请号：

PH12015000304

公开号：

PH12015000304A1

申请日:

2015.09.10

申请国别(地区):

PH

年份:

2017

代理人:

摘要：

The present invention relates to the formulation of Aloin Schiff Base (ASB) a potential drug to prevent lung cancer caused by inhalation of ions of iron. The ASB was synthesized using ammonium hydroxide. The best concentration of ASB to chelate Fe3+ was found to be 25 pcnt . This concentration of ASB was liposome encapsulated producing a nanoparticle (51 nm) suited for intranasal delivery. The successful intranasal delivery of ASB in the lung macrophages and the consequent chelation of iron was established.

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中国工程科技知识中心

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