KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;한국생명공학연구원
发明人:
WON, Mi Sun,원미선,BAN, Hyun Seung,반현승,KIM, Bo Kyung,김보경,NAM, Soon Woo,남순우,LEE, Kyeong,이경,LEE, Young-Ju,이영주,LEE, Hong-Sub,이홍섭,KIM, Dong Uk,김동욱,PARK, Ki Cheol,박기철
申请号：
KRKR2014/009204
公开号：
WO2015/050364A1
申请日:
2014.09.30
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing and treating cancer, containing cytochrome b5 reductase 3 (cyb5R3) protein as an active ingredient. The expression of hypoxia-inducible factor-1 (HIF-1) is significantly reduced in cancer cells overexpressing cyb5R3 so as to inhibit the growth of cancer cells and effectively inhibit in vivo tumor growth and metastasis, and thus the cyb5R3 gene or protein of the present invention can be useful as an active ingredient of a pharmaceutical composition for preventing and treating cancer.La présente invention concerne une composition pharmaceutique pour prévenir et traiter un cancer, contenant la protéine cytochrome b5 réductase 3 (cyb5R3) en tant que substance active. L'expression du facteur inductible par l'hypoxie 1 (HIF-1) est significativement réduite dans les cellules cancéreuses surexprimant cyb5R3 de manière à inhiber la croissance de cellules cancéreuses et inhiber efficacement la croissance et la métastase de tumeur in vivo, et par conséquent, le gène ou la protéine cyb5R3 de la présente invention peut être utile en tant que substance active d'une composition pharmaceutique pour prévenir et traiter un cancer.본 발명은 싸이토크롬 b5 환원효소 3(cytochrome b5 reductase 3； cyb5R3) 단백질을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물에 관한 것으로, 상기 cyb5R3을 과다발현하는 암세포에서 저산소 유도 인자-1(Hypoxia-inducible factor-1； HIF-1)의 발현이 유의적으로 감소하여 암세포의 생장을 억제하며, 생체 내에서 종양의 성장 및 전이를 효과적으로 억제하므로, 본 발명의 cyb5R3 유전자 또는 단백질은 암 예방 및 치료용 약학적 조성물의 유효성분으로 유용하게 사용될 수 있다.
