Tianxiao Sun,Philip M. Levesque,Alicja T. Brown,Cynthia K. Lee
申请号：
US14992350
公开号：
US09821064B2
申请日:
2016.01.11
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed herein is a formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae:wherein R1, R2, and R3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms； an inorganic salt； glutamic acid or a salt thereof； a polyol； a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. The tertiary amine N-oxide may be trimethylamine-N-oxide, (CH3)3NO. The formulation is useful for vaccine stabilization.
