CRITCHLEY, STEPHEN,GANT, THOMAS G.,LANGSTON, STEVEN P.,OLHAVA, EDWARD J.,PELUSO, STEPHANE
申请号：
PL06734691
公开号：
PL1848718T3
申请日:
2006.02.02
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
This invention relates to compounds of formula (I-A) wherein Ring A and the variables X, Y, R3a, R3b, R3c, R3d, R4, R5, R5&prime；, and m are defined herein. The compounds of formula (I-A) inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds of the invention are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders； and inflammation associated with infection and cachexia.
