The invention concerns substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2 -one, more particularly for therapeutic purposes, pharmaceutical means and the use thereof in treatment, in particular for prophylaxis and for the treatment of tumorous diseases.Compuestos de 3-(bifenil-3-iI)-4-hidroxi-8-metoxi-1 -azaespiro[4.5]dec- 3-en-2-onas sustituidas, en particular para fines terapéuticos, composiciones farmacéuticas y su uso en terapias, en particular para la profilaxis y terapia de trastornos neoplásicos.