METHODS FOR MODULATING MONOCYTE FUNCTION

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专利权人:

发明人:

Julia Brittain,Ciprian Anea,Itia Lee

申请号：

US14923932

公开号：

US20160113936A1

申请日:

2015.10.27

申请国别(地区):

US

年份:

2016

代理人:

摘要：

It has been discovered that HSP90 inhibitors can inhibit both the pro-inflammatory and pro-coagulatory potential of monocytes, in particular activated monocytes. One embodiment provides a method of inhibiting the pro-inflammatory phenotype of monocytes, preferably in human subjects, most preferably in human subjects having Sickle Cell Disease (SCD). A preferred HSP90 inhibitor is 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide (NVP-AUY922).

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中国工程科技知识中心

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