RIESBECK, KRISTIAN,DORLING, ANTHONY,GEORGE, ANDREW JOHN TIMOTHY,LECHLER, ROBERT IAN
申请号：
CA2285702
公开号：
CA2285702C
申请日:
1998.03.26
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention relates to the inhibition of blood coagulation, especiallyduring organ rejection, and in particular the inhibition of delayed vascularrejection. The invention provides anticoagulant proteins which are anchored tocell membranes. The anticoagulant function is preferably provided by heparin,antithrombin, hirudin, TFPI, tick anticoagulant peptide, or a snake venomfactor. These anticoagulant proteins are preferably prevented from beingconstitutively expressed at the cell surface. In particular, expression at thecell surface is regulated according to cell activation, for instance bytargeting the protein to a suitable secretory granule. Expression of theseproteins renders cells, tissues and organs less vulnerable to rejection aftertransplantation (e.g. after xenotransplantation).
