The present invention primarily relates to specific uses of a composition containing a roasted extract and xanthohumol for health promoting purposes. In particular the invention relates to a composition preferably pharmaceutical composition comprising xanthohumol (XN) preferably in a therapeutically effective amount for (i) use in the treatment and/or prevention of cancer and/or (ii) use in the treatment and/or prevention of osteoporosis and/or (iii) use in the treatment and/or prevention of metabolic syndrome and/or (iv) use in the treatment and/or prevention of diabetes and/or (v) use in the treatment and/or prevention of cardiovascular disease(s) and/or (vi) use as anti oxidant and/or (vii) use as detoxifying agent and/or (viii) inhibiting metabolic activation of procarcinogenes and/or (ix) use as anti mutagenic and/or anti genotoxic agent and/or (x) use as anti estrogenic and/or estrogenic agent and/or (xi) inducing apoptosis and/or (xii) use as anti angiogenetic agent and/or (xiii) use as anti inflammatory agent and/or (xiv) inhibiting NF ?? and/or (xv) use in the treatment and/or prevention of infection(s) in particular use as antimicrobial agent wherein the composition comprises or consists of (a) a roasted extract and (b) XN preferably a hop extract comprising XN and/or wherein the composition is obtainable or obtained by mixing (a) a roasted extract and (b) XN or preferably a hop extract comprising XN.
