LAFRANCE, Danny,HOGAN, Philip,LIU, Yansheng,HE, Minsheng,CHEN, Chi-Li,NIU, John
申请号：
PH12019500822
公开号：
PH12019500822A1
申请日:
2019.04.15
申请国别(地区):
PH
年份:
2019
代理人:
摘要：
The invention relates to crystalline forms of the bis-HCI salt of a compound represented by Structural Formula 1, and pharmaceutical compositions comprising crystalline forms of the bis-HCL salt of a compound represented by Structural Formula 1 described herein. The crystalline forms of the bis-HCI salt of a compound of Structural Formula 1 and compositions comprising the crystalline forms of the compound of Structural Formula 1 provided herein, in particular, crystalline Form I, crystalline Form J, crystalline Form A, and crystalline Form B, or mixtures thereof, can be incorporated into pharmaceutical compositions, which can be used to treat various disorders. Also described herein are methods for preparing the crystalline forms (e.g., Forms I, J, B and A) of the bis-HCI salt of a compound represented by Structural Formula 1.
