Disclosed in the present invention are a hot plasma disease treatment system and a method of use thereof, comprising a mutually connected control system and at least one power supply system, the control system and the power supply system respectively being connected to and controlling a medium gas modulation system, at least one cooling system, at least one hot plasma generator, at least one plasma processing apparatus, a plasma treatment cabin, a detection feedback system, and a tail gas processing system, the medium gas modulation system being connected to the hot plasma generator, the cooling system being arranged on the hot plasma generator, the hot plasma generator and the plasma processing apparatus being connected, the plasma processing apparatus and the plasma treatment cabin being connected, and the plasma treatment cabin and the tail gas processing system being connected. The present invention can treat various diseases including body surface disease, in vivo viral disease, tumorous disease, immune system disease, and nervous system degenerative disease, providing a novel treatment system and method for the treatment of disease.
