BEBBINGTON, DAVID,CHARRIER, JEAN-DAMIEN,GOLEC, JULIAN,MILLER, ANDREW,KNEGTEL, RONALD
申请号：
ES06011799
公开号：
ES2375491T3
申请日:
2001.12.19
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula IIIa: 1. or a pharmaceutically acceptable salt thereof, wherein: Rx and Ry are selected from T-R3 or L-Z-R3； R1 is T- (Ring D)； Ring D is a 5-7 membered monocyclic ring or an 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl, said heteroaryl or heterocyclyl ring having 1-4 heteroatoms in the ring selected from nitrogen, oxygen or sulfur, in which each substitutable carbon atom of ring D is independently substituted by oxo, T-R5, or VZ-R5, and each substitutable nitrogen atom of ring D is independently substituted by -R4； T is a valence bond or a C1-4 alkylidene chain； Z is a C1-4 alkylidene chain； L is -O-, -S-, -SO-, -SO2-, -N (R6) SO2-, -SO2N (R6) -, -N (R6) -, -CO-, -CO2-, -N (R6) CO-, -N (R6) C (O) O-, - N (R6) CON (R6) -, -N (R6) SO2N (R6) -, -N (R6) N (R6) - , -C (O) N (R6) -, -OC (O) N (R6) -, -C (R6) 2O-, -C (R6) 2S-, -C (R6) 2SO-, - C ( R6) 2SO2-, -C (R6) 2SO2N (R6) -, -C (R6) 2N (R6) -, -C (R6) 2N (R6) C (O) -, -C (R6) 2N (R6 ) C (O) O-, -C (R6) = NN (R6) -, - C (R6) = NO-, -C (R6) 2N (R6) N (R6) -, -C (R6) 2N (R6) SO2N (R6) -, or -C (R6) 2N (R6) CON (R6) -； R2 and R2 'are taken together with their intermediate atoms to form a condensed ring selected from pyrido, pyrimide and a 6-membered unsaturated carbocyclic ring, wherein each replaceable carbon atom of the ring of said condensed ring formed by R2 and R2' is independently substituted by halo, oxo, -CN, -NO2, -R7, or -V-R6, and each substitutable nitrogen atom of the ring of said ring formed by R2 and R2 'is independently substituted by R4； R3 is selected from -R, -halo, -OR, -C (= O) R, -CO2R, -COCOR, -COCH2COR, -NO2, -CN, -S (O) R, -S (O) 2R, -SR, -N (R4) 2, -CON (R7) 2, -SO2N (R7) 2, -OC (= O) R, -N (R7) COR, -N (R7) CO2 (C1-aliphatic) 6), -N (R4) N (R4) 2, -C = NN (R4) 2, - C = NOR, -N (R7) CON (R7) 2, -N (R7) SO2N (R7) 2, -N (R4) SO2R, or -OC (= O) N (R7) 2； each R is independently selected from hydrogen or an optionally substituted group
