Disclosed is an isolated, recombinant or purified antibody that specifically binds to CSF-1 R, wherein said antibody comprises: (i) (a) first variable region consisting in SEQ 10 NO:42, and (b) a second variable region consisting in SEQ ID NO:44 or (ii) (a) first variable region consisting in SEQ 10 NO:43, and (b) a second variable region consisting in SEQ ID NO:45 or (iii) (a) first variable region consisting in SEQ 10 NO:42, and (b) a second variable region consisting in SEQ ID NO:46.